Can Eating Citrus Prevent Depression? A surprising new study suggests that a small, delicious change in diet may significantly reduce the risk of depression. Research published in Microbiome (2024) found that individuals who consume the most citrus fruits have a 22% lower risk of depression compared to those who eat the least. Even better? Achieving this benefit is simple—you only need to eat about one medium orange a day. The Citrus Connection: How It Works The study uncovered a fascinating link between citrus consumption